Summary: The immune-genetic changes that occur in cancer patients experiencing hyperprogressive disease (HPD) during combined immunotherapy are unclear.In this study, HPD patients with pre- and post-HPD samples and non-HPD patients with solid tumors were molecularly characterized by genetic and tumor immune microenvironment (TiME) analyses of paire
Plant diseases compose a great threat to global food security.However, the rapid identification of plant diseases remains challenging and time-consuming.It requires experts to accurately Goalie - Protective identify if the plant is healthy or not and identify the type of infection.Deep learning techniques have recently been used to identify and dia
Background and Objectives: Genetic diversity of Mycobacterium tuberculosis clinical isolates from tuberculosis patients in the multiethnic province of Alborz, Iran was assessed.Materials and Methods: A total of 17 isolates in the period of 2012-2013 were collected and subjected to a Multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA
Social support, when provided following a traumatic experience, is associated with a lower incidence of stress-related psychiatric disorders.Our hypothesis was that providing a social interaction period with a naive conspecific would improve sleep architecture in response to cued fear conditioning in Wistar rats.Rats were randomly assigned to eithe
This paper deals with the issue of safety lead time (SLT) calculations in production-inventory systems in presence of both demand and replenishment lead time variability.We provide some formulations of the SLT and numerically show their performance as compared to a benchmark in the literature.Thus the main objective of this paper is to provide anal